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Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult

Title
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult
Authors
Park J.S.Park H.Park S.Kim S.J.Seol H.J.Ko Y.-H.
Ewha Authors
박상희
SCOPUS Author ID
박상희scopus
Issue Date
2013
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 54, no. 3, pp. 791 - 796
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intrace-rebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an absence of involvement in any other organs; specifically, the primary central nervous system ALKALCL. Complete remission was achieved following 5 cycles of systemic chemotherapy with a high dose of Methotrexate and a simultaneous 7 cycles of intrathecal triple chemotherapy. Diagnosis of primary leptomeningeal ALK+ALCL is challenging given its rarity and non-specific symptoms along with non-pathognomonic radiologic findings. We present the first case of primary leptomeningeal ALK-positive ALCL where the clinical course, pathologic characteristics and treatment modality are described as well as a review of literature. © Yonsei University College of Medicine 2013.
DOI
10.3349/ymj.2013.54.3.791
Appears in Collections:
의과대학 > 의학과 > Journal papers
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