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Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Title
Concepts and practices used to develop functional PLGA-based nanoparticulate systems
Authors
Sah H.Thoma L.A.Desu H.R.Sah E.Wood G.C.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2013
Journal Title
International Journal of Nanomedicine
ISSN
1176-9114JCR Link
Citation
vol. 8, pp. 747 - 765
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shell-type lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner. © 2013 Sah et al, publisher and licensee Dove Medical Press Ltd.
DOI
10.2147/IJN.S40579
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약학대학 > 약학과 > Journal papers
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