View : 85 Download: 0

Aripiprazole-montmorillonite: A new organic-inorganic nanohybrid material for biomedical applications

Title
Aripiprazole-montmorillonite: A new organic-inorganic nanohybrid material for biomedical applications
Authors
Oh Y.-J.Choi G.Choy Y.B.Park J.W.Park J.H.Lee H.J.Yoon Y.J.Chang H.C.Choy J.-H.
Ewha Authors
이화정윤여준최진호박제원
SCOPUS Author ID
이화정scopus; 윤여준scopus; 최진호scopus
Issue Date
2013
Journal Title
Chemistry - A European Journal
ISSN
0947-6539JCR Link
Citation
vol. 19, no. 15, pp. 4869 - 4875
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Poor aqueous solubility and the unpleasant taste of aripiprazole (APZ) have been recurring problems, owing to its low bioavailability and low patient tolerance, respectively. Herein, we prepared a nanohybrid system that was based on a bentonite clay material, montmorillonite (MMT), which could both mask the taste and enhance the solubility of APZ (i.e., APZ-MMT). To further improve the efficacy of this taste masking and drug solubility, APZ-MMT was also coated with a cationic polymer, polyvinylacetal diethylamino acetate (AEA). In vitro dissolution tests at neutral pH showed that the amount of drug that was released from the AEA-coated APZ-MMT was greatly suppressed (<1 %) for the first 3 min, thus suggesting that AEA-coated APZ-MMT has strong potential for the taste masking of APZ. Notably, in simulated gastric juice at pH 1.2, the total percentage of APZ that was released within the first 2 h increased up to 95 % for AEA-coated APZ-MMT. Furthermore, this in vitro release profile was also similar to that of Abilify®, a commercially available medication. In vivo experiments by using Sprague-Dawley rats were also performed to compare the pharmacokinetics of AEA-coated APZ-MMT and Abilify®. AEA-coated APZ-MMT exhibited about 20 % higher systemic exposure of APZ and its metabolite, dehydro-APZ, compared with Abilify®. Therefore, a new MMT-based nanovehicle, which is coated with a cationic polymer, can act as a promising delivery system for both taste masking and for enhancing the bioavailability of APZ. Please release me: From an in vitro release study, the drug-release fraction for the AEA-coated aripiprazole-montmorillonite (APZ-MMT) hybrid material was determined to be enhanced up to about 95 % in simulated gastric solution (see figure; AEA=polyvinylacetal diethylamino acetate). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
DOI
10.1002/chem.201203384
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE