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Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Title
Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit
Authors
Ban Y.H.Lee J.H.Gu G.R.Lee B.Mo S.Kwon H.J.Yoon Y.J.
Ewha Authors
윤여준모상준
SCOPUS Author ID
윤여준scopus
Issue Date
2013
Journal Title
Molecular BioSystems
ISSN
1742-206XJCR Link
Citation
vol. 9, no. 5, pp. 944 - 947
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined. © 2013 The Royal Society of Chemistry.
DOI
10.1039/c2mb25419k
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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