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Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis

Title
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis
Authors
Choi H.K.Kang H.R.Jung E.Kim T.E.Lin J.J.Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2013
Journal Title
Cell Research
ISSN
1001-0602JCR Link
Citation
vol. 23, no. 4, pp. 524 - 536
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The receptor activator of NF-κB (RANK) and immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors are essential factors involved in regulating osteoclast formation and bone remodeling. Here, we identify early estrogen-induced gene 1 (EEIG1) as a novel RANK ligand (RANKL)-inducible protein that physically interacts with RANK and further associates with Gab2, PLCγ2 and Tec/Btk kinases upon RANKL stimulation. EEIG1 positively regulates RANKL-induced osteoclast formation, likely due to its ability to facilitate RANKL-stimulated PLCγ2 phosphorylation and NFATc1 induction. In addition, an inhibitory peptide designed to block RANK-EEIG1 interaction inhibited RANKL-induced bone destruction by reducing osteoclast formation. Together, our results identify EEIG1 as a novel RANK signaling component controlling RANK-mediated osteoclast formation, and suggest that targeting EEIG1 might represent a new therapeutic strategy for the treatment of pathological bone resorption. © 2013 IBCB, SIBS, CAS All rights reserved.
DOI
10.1038/cr.2013.33
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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