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OASL1 inhibits translation of the type i interferon-regulating transcription factor IRF7

Title
OASL1 inhibits translation of the type i interferon-regulating transcription factor IRF7
Authors
Lee M.S.Kim B.Oh G.T.Kim Y.-J.
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2013
Journal Title
Nature Immunology
ISSN
1529-2908JCR Link
Citation
vol. 14, no. 4, pp. 346 - 355
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory responses. Here we found that OASL1 inhibited translation of IRF7, the master transcription factor for type I interferon, and thus negatively regulated the robust production of type I interferon during viral infection. OASL1 inhibited the translation of IRF7 mRNA by binding to the 5′ untranslated region (UTR) of IRF7 and possibly by inhibiting scanning of the 43S preinitiation complex along the message. Oasl1-/- mice were resistant to viral infection because of the greater abundance of type I interferon, which suggests that OASL1 could be a potential therapeutic target for boosting the production of type I interferon during viral infection. © 2013 Nature America, Inc. All rights reserved.
DOI
10.1038/ni.2535
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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