Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8- dihydroisoquinoline-4-carboxylates

Abstract

7-Arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Most of tested compounds showed good antifungal activity. The results suggest that those 5,8-dioxo-5,8-dihydroisoquinolines would be potent antifungal agents. © 2013 Elsevier Ltd. All rights reserved.