View : 21 Download: 0

Dimerization of TCTP and its clinical implications for allergy

Title
Dimerization of TCTP and its clinical implications for allergy
Authors
Kim M.Maeng J.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
2013
Journal Title
Biochimie
ISSN
0300-9084JCR Link
Citation
vol. 95, no. 4, pp. 659 - 666
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Following the detection of histamine-releasing activity (HRA) in the supernatants of peripheral blood mononuclear cell cultures, research efforts were directed at characterizing the source of this activity, mostly focusing, on IgE-dependent histamine-releasing factors (HRFs). HRF is now variously called translationally controlled tumor protein (TCTP), p21, p23, and fortilin. TCTP exhibits cytokine-like functions including release of histamine, induction of TH2 cytokines and chemoattractants, augmentation of B cell proliferation, and immunoglobulin production during late phase allergic inflammation. Because of its association with the allergic status of patients, TCTP emerged as a potential key agent in the modulation of allergic diseases. Several lines of evidence suggest that TCTP exhibits its cytokine-like functions only after it is modified by the proteases, altered oxidant-antioxidant balance and immunoglobulin E, present in the inflamed sites. This review will try to show that dimerization is the critical modification of TCTP if not the only modification, responsible for its cytokine-like activity causing allergic diseases. © 2012 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.biochi.2012.10.007
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE