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Zinc sensors with lower binding affinities for cellular imaging

Title
Zinc sensors with lower binding affinities for cellular imaging
Authors
Kim J.H.Hwang I.H.Jang S.P.Kang J.Kim S.Noh I.Kim Y.Kim C.Harrison R.G.
Ewha Authors
김영미
SCOPUS Author ID
김영미scopus
Issue Date
2013
Journal Title
Dalton Transactions
ISSN
1477-9226JCR Link
Citation
vol. 42, no. 15, pp. 5500 - 5507
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn2+ and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions. In vitro studies with fibroblasts showed fluorescence when sensor and Zn2+ were present. As seen by single crystal X-ray analysis, four nitrogens from the sensor bind to Zn2+. These new sensors have lower binding constants than the pentadentate sensors based on 2,2-DPA. © 2013 The Royal Society of Chemistry.
DOI
10.1039/c3dt33024a
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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