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Statistical properties of amplitude and decay parameter estimators for fluorescence lifetime imaging

Title
Statistical properties of amplitude and decay parameter estimators for fluorescence lifetime imaging
Authors
Kim J.Seok J.
Ewha Authors
김정태
SCOPUS Author ID
김정태scopus
Issue Date
2013
Journal Title
Optics Express
ISSN
1094-4087JCR Link
Citation
vol. 21, no. 5, pp. 6061 - 6075
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We analyze the statistical properties of the maximum likelihood estimator, least squares estimator, and Pearson's χ2-based and Neyman's χ2-based estimators for the estimation of decay constants and amplitudes for fluorescence lifetime imaging. Our analysis is based on the linearization of the gradient of the objective functions around true parameters. The analysis shows that only the maximum likelihood estimator based on the Poisson likelihood function yields unbiased and efficient estimation. All other estimators yield either biased or inefficient estimations. We validate our analysis by using simulations. © 2013 Optical Society of America.\e.
DOI
10.1364/OE.21.006061
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
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