Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 류재상 | * |
dc.date.accessioned | 2016-08-28T10:08:28Z | - |
dc.date.available | 2016-08-28T10:08:28Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-9782 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223452 | - |
dc.description.abstract | JNKs (c-Jun N-terminal kinases) have the potential to serve as a therapeutic target for various inflammatory, vascular, neurodegenerative, metabolic and oncological diseases. In particular, ATP-competitive JNK3 inhibitors act as neuroprotective agents. Here we introduce 1,2-diaryl-1H- benzimidazole derivatives as selective JNK3 inhibitors from among our in-house compounds and describe our elucidation of their SAR using 3D-QSAR models. A predictive CoMFA model (q2 = 0.795, r2 = 0.931) and a CoMSIA model (q2 = 0.700, r2 = 0.937) were used to describe the non-linearly combined affinity of each functional group in the inhibitors. © 2013 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | 3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1639 | * |
dc.relation.lastpage | 1642 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2013.01.082 | * |
dc.identifier.wosid | WOS:000315331500013 | * |
dc.identifier.scopusid | 2-s2.0-84874663812 | * |
dc.author.google | Kim M.-H. | * |
dc.author.google | Ryu J.-S. | * |
dc.author.google | Hah J.-M. | * |
dc.contributor.scopusid | 류재상(36081118200) | * |
dc.date.modifydate | 20231120165709 | * |