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Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression

Title
Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression
Authors
Kim J.-M.Noh E.-M.Kwon K.-B.Kim J.-S.You Y.-O.Hwang J.-K.Hwang B.-M.Kim M.S.Lee S.-J.Jung S.-H.Youn H.-J.Chung E.-Y.Lee Y.-R.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2013
Journal Title
Oncology Reports
ISSN
1021-335XJCR Link
Citation
vol. 29, no. 3, pp. 1231 - 1237
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cell invasion is required for neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in the process of cancer cell invasion. Sulfuretin is one of the major flavonoids isolated from Rhus verniciflua. Sulfuretin has been used to reduce oxidative stress, platelet aggregation, the inflammatory response and mutagenesis. However, the effect of sulfuretin on breast cancer metastasis is unknown. In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Sulfuretin inhibited TPA-induced transcriptional activation of nuclear factor-κB (NF-κB). We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-κB pathway. Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness.
DOI
10.3892/or.2012.2218
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약학대학 > 약학과 > Journal papers
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