Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 류재상 | * |
dc.date.accessioned | 2016-08-28T10:08:24Z | - |
dc.date.available | 2016-08-28T10:08:24Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-9725 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223401 | - |
dc.description.abstract | A series of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles has been synthesized and evaluated for their ALK5 inhibitory activity. The 1-(6-methylpyridin-2-yl)-1,2,3-triazoles were assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition. Following this, quinoxaline was introduced through Pd-catalyzed direct arylation. The synthesized 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles revealed significant selectivity differences with respect to p38α MAP kinase. In particular, 12k showed 80.8% ALK5 inhibitory activity at a concentration of 10 μM and IC50 value of 4.69 μM, but did not show p38α MAP kinase inhibitory activity (-1.94% inhibition at a concentration of 10 μM). © 2012 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5- (quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1083 | * |
dc.relation.lastpage | 1086 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2012.12.008 | * |
dc.identifier.wosid | WOS:000314625400032 | * |
dc.identifier.scopusid | 2-s2.0-84872939277 | * |
dc.author.google | Li F. | * |
dc.author.google | Park Y. | * |
dc.author.google | Hah J.-M. | * |
dc.author.google | Ryu J.-S. | * |
dc.contributor.scopusid | 류재상(36081118200) | * |
dc.date.modifydate | 20231120165709 | * |