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Brominated aromatic furanones and related esters from the ascidian synoicum sp.

Title
Brominated aromatic furanones and related esters from the ascidian synoicum sp.
Authors
Won T.H.Jeon J.-E.Kim S.-H.Lee S.-H.Rho B.J.Oh D.-C.Oh K.-B.Shin J.
Ewha Authors
노분조
SCOPUS Author ID
노분조scopusscopus
Issue Date
2012
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 75, no. 12, pp. 2055 - 2061
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nine new compounds, tris-aromatic furanones (1, 2, 3a, 3b, and 4) and related bis-aromatic diesters (5a, 5b, 6a, and 6b), are described from the ascidian Synoicum sp. collected off the coast of Chuja-do, Korea. The structures of these compounds, designated as cadiolides E and G-I (1-4) and synoilides A and B (5 and 6), were determined by extensive spectroscopic analyses. The absolute configuration at the asymmetric center of cadiolide G (2) was assigned by ECD analysis. Of these new compounds, cadiolide I and the synoilides possess unprecedented carbon skeletons. Several of these compounds exhibited significant inhibition against diverse bacterial strains as well as moderate inhibition against the enzymes sortase A, isocitrate lyase, and Na+/K +-ATPase. © 2012 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np3005562
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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