Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Abstract

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones. © 2012 American Chemical Society.