Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-28T10:08:12Z | - |
dc.date.available | 2016-08-28T10:08:12Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1226-3613 | * |
dc.identifier.other | OAK-9567 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223275 | - |
dc.description.abstract | KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)- N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro- 2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemiareperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive oxygen species production. In this study, we investigated the anti-inflammatory and anti-atherogenic properties of KR-31543. We observed that KR-31543 treatment reduced the production of MCP-1, IL-8, and VCAM-1 in HUVECs, and of MCP-1 and IL-6 in THP-1 human monocytes. We also examined the effect of KR-31543 on monocytes migration in vitro. KR-31543 treatment effectively reduced the migration of THP-1 human monocytes to the HUVEC monolayer in a dose-dependent manner. We next examined the effects of this compound on atherogenesis in LDL receptor deficient (Ldlr -/-) mice. After 10 weeks of western diet, the formation of atherosclerotic lesion in aorta was reduced in the KR-31543-treated group compared to the control group. The accumulation of macrophages in lesion was also reduced in KR-31543 treated group. However, the plasma levels of total cholesterol, HDL, LDL, and triglyceride were not affected by KR-31543 treatment. Taken together, these results show that KR-31543 has anti-inflammatory properties on human monocytes and endothelial cells, and inhibits fatty streak lesion formation in mouse model of atherosclerosis, suggesting the potential of KR-31543 for the treatment for atherosclerosis. © 2012 by the Korean Society for Biochemistry and Molecular Biology. | * |
dc.language | English | * |
dc.title | KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 733 | * |
dc.relation.lastpage | 739 | * |
dc.relation.journaltitle | Experimental and Molecular Medicine | * |
dc.identifier.doi | 10.3858/emm.2012.44.12.081 | * |
dc.identifier.wosid | WOS:000312516600003 | * |
dc.identifier.scopusid | 2-s2.0-84871350243 | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Yoo J.-Y. | * |
dc.author.google | Kim S.-O. | * |
dc.author.google | Yoo S.-E. | * |
dc.author.google | Oh G.T. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |