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Nanogap-based dielectric-specific colocalization for highly sensitive surface plasmon resonance detection of biotin-streptavidin interactions

Title
Nanogap-based dielectric-specific colocalization for highly sensitive surface plasmon resonance detection of biotin-streptavidin interactions
Authors
Kim Y.Chung K.Lee W.Ha Kim D.Kim D.
Ewha Authors
김동하
SCOPUS Author ID
김동하scopus
Issue Date
2012
Journal Title
Applied Physics Letters
ISSN
0003-6951JCR Link
Citation
vol. 101, no. 23
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have performed highly sensitive surface plasmon resonance (SPR) detection by colocalizing the evanescent near-fields and target molecular distribution. The colocalization is based on oblique metal evaporation to form nanogaps of a size under 100 nm without using electron-beam lithography. The concept was demonstrated by detecting siloxane-based biotin/streptavidin interactions. 50-nm nanogaps produced the largest amplification of optical signatures and two orders of magnitude enhancement of sensitivity over conventional thin film-based measurements. The enhancement is associated with efficient overlap of localized near-fields and target. Colocalized detection scheme is expected to provide clues to molecular sensitivity for SPR biosensing. © 2012 American Institute of Physics.
DOI
10.1063/1.4769108
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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