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Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

Title
Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells
Authors
Oh S.-W.Lee J.B.Kim B.Jeon S.Kim M.-K.Nam K.-H.Ha J.-R.Bhatia M.Oh G.T.Kim D.-Y.
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2012
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 35, no. 11, pp. 1979 - 1988
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify compounds that promote cardiomyogenesis of stem cells, cell-based screening of a peptidomimetic small-molecule library was carried out. A series of β-turn peptidomimetic compounds, including CW209E, increased the expression of α-MHC promoter-driven enhanced green fluorescent protein (EGFP) and ratio of beating embryoid bodies (EBs) without inducing cytotoxicity in mouse embryonic stem cells. CW209E also increased the number of beating EBs in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Thus, this chemical compound should be useful for elucidation of the molecular pathway of cardiogenesis and generation of cardiomyocytes ex vivo, which can be further applied for experimental or clinical cell therapy for ischemic heart diseases. © 2012 The Pharmaceutical Society of Korea and Springer Science+Business Media Dordrecht.
DOI
10.1007/s12272-012-1115-6
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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