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2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

Title
2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways
Authors
Park S.R.Park J.W.Ban Y.H.Sohng J.K.Yoon Y.J.
Ewha Authors
윤여준박제원
SCOPUS Author ID
윤여준scopus
Issue Date
2013
Journal Title
Natural Product Reports
ISSN
0265-0568JCR Link
Citation
vol. 30, no. 1, pp. 11 - 20
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Covering: 2007 to September 2012 The 2-deoxystreptamine-containing aminoglycosides, such as neomycin, kanamycin and gentamicin, are an important class of antibiotics. A detailed understanding of the complete biosynthetic pathway of aminoglycosides and their biosynthetic enzymes will allow us to not only generate more robust antibiotic agents or drugs with other altered biological activities, but also to produce clinically important semi-synthetic antibiotics by direct fermentation. This Highlight focuses on recent advances in the characterization of their biosynthetic enzymes and pathway as well as some chemo-enzymatic and metabolic engineering approaches for the biological production of natural, semi-synthetic, and novel aminoglycosides. This journal is © The Royal Society of Chemistry 2012.
DOI
10.1039/c2np20092a
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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