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Experimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4

Title
Experimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4
Authors
Chung J.-Y.Bae Y.-A.Yun D.-H.Yang H.-J.Kong Y.
Ewha Authors
양현종
SCOPUS Author ID
양현종scopus
Issue Date
2012
Journal Title
Korean Journal of Parasitology
ISSN
0023-4001JCR Link
Citation
vol. 50, no. 4, pp. 301 - 308
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 postinfection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes signifcantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection. © 2012, Korean Society for Parasitology and Tropical Medicine.
DOI
10.3347/kjp.2012.50.4.301
Appears in Collections:
의과대학 > 의학과 > Journal papers
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