Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양현종 | - |
dc.date.accessioned | 2016-08-28T10:08:08Z | - |
dc.date.available | 2016-08-28T10:08:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.other | OAK-9532 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223246 | - |
dc.description.abstract | In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 postinfection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes signifcantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection. © 2012, Korean Society for Parasitology and Tropical Medicine. | - |
dc.language | English | - |
dc.title | Experimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4 | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 50 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 301 | - |
dc.relation.lastpage | 308 | - |
dc.relation.journaltitle | Korean Journal of Parasitology | - |
dc.identifier.doi | 10.3347/kjp.2012.50.4.301 | - |
dc.identifier.wosid | WOS:000312056400004 | - |
dc.identifier.scopusid | 2-s2.0-84870813594 | - |
dc.author.google | Chung J.-Y. | - |
dc.author.google | Bae Y.-A. | - |
dc.author.google | Yun D.-H. | - |
dc.author.google | Yang H.-J. | - |
dc.author.google | Kong Y. | - |
dc.contributor.scopusid | 양현종(7406561974) | - |
dc.date.modifydate | 20180329112215 | - |