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dc.contributor.author양현종-
dc.date.accessioned2016-08-28T10:08:08Z-
dc.date.available2016-08-28T10:08:08Z-
dc.date.issued2012-
dc.identifier.issn0023-4001-
dc.identifier.otherOAK-9532-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223246-
dc.description.abstractIn fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 postinfection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes signifcantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection. © 2012, Korean Society for Parasitology and Tropical Medicine.-
dc.languageEnglish-
dc.titleExperimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume50-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage301-
dc.relation.lastpage308-
dc.relation.journaltitleKorean Journal of Parasitology-
dc.identifier.doi10.3347/kjp.2012.50.4.301-
dc.identifier.wosidWOS:000312056400004-
dc.identifier.scopusid2-s2.0-84870813594-
dc.author.googleChung J.-Y.-
dc.author.googleBae Y.-A.-
dc.author.googleYun D.-H.-
dc.author.googleYang H.-J.-
dc.author.googleKong Y.-
dc.contributor.scopusid양현종(7406561974)-
dc.date.modifydate20180329112215-
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의과대학 > 의학과 > Journal papers
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