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Ginseng berry extract prevents atherogenesis via anti-inflammatory action by upregulating phase II gene expression

Title
Ginseng berry extract prevents atherogenesis via anti-inflammatory action by upregulating phase II gene expression
Authors
Kim C.-K.Cho D.H.Lee K.-S.Lee D.-K.Park C.-W.Kim W.G.Lee S.J.Ha K.-S.Goo Taeg O.Kwon Y.-G.Kim Y.-M.
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2012
Journal Title
Evidence-based Complementary and Alternative Medicine
ISSN
1741-427XJCR Link
Citation
vol. 2012
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Ginseng berry possesses higher ginsenoside content than its root, which has been traditionally used in herbal medicine for many human diseases, including atherosclerosis. We here examined the antiatherogenic effects of the Korean ginseng berry extract (KGBE) and investigated its underlying mechanism of action in vitro and in vivo. Administration of KGBE decreased atherosclerotic lesions, which was inversely correlated with the expression levels of phase II genes to include heme oxygenase-1 (HO-1) and glutamine-cysteine ligase (GCL). Furthermore, KGBE administration suppressed NF-B-mediated expression of atherogenic inflammatory genes (TNF-α, IL-1β, iNOS, COX-2, ICAM-1, and VCAM-1), without altering serum cholesterol levels, in ApoE-/- mice fed a high fat-diet. Treatment with KGBE increased phase II gene expression and suppressed lipopolysaccharide-induced reactive oxygen species production, NF-B activation, and inflammatory gene expression in primary macrophages. Importantly, these cellular events were blocked by selective inhibitors of HO-1 and GCL. In addition, these inhibitors reversed the suppressive effect of KGBE on TNF-α-mediated induction of ICAM-1 and VCAM-1, resulting in decreased interaction between endothelial cells and monocytes. These results suggest that KGBE ameliorates atherosclerosis by inhibiting NF-B-mediated expression of atherogenic genes via upregulation of phase II enzymes and thus has therapeutic or preventive potential for atherosclerosis. © 2012 Chun-Ki Kim et al.
DOI
10.1155/2012/490301
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자연과학대학 > 생명과학전공 > Journal papers
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