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Induction of classical activation of macrophage in vitro by water soluble chitin

Title
Induction of classical activation of macrophage in vitro by water soluble chitin
Authors
Jeon D.-W.Ahn W.S.You S.J.Chae G.T.Shim Y.B.Chun H.J.
Ewha Authors
전동원
Issue Date
2012
Journal Title
Applied Surface Science
ISSN
0169-4332JCR Link
Citation
vol. 262, pp. 134 - 139
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The purpose of this study is to understand the effect of chitin on macrophage mediated immunity, which is a significant factor to wound healing and tissue regeneration. In this work, water soluble chitin (WSC) was prepared by re-acetylation of chitosan and was treated with the murine RAW 264.7 macrophage cell lines (ATCC TIB-71). WSC induced classical activation in the RAW 264.7 cells, accompanied by the induction of associated genes. The results suggest that WSC is one of the functional chitin molecules that are responsible for the immune response, especially present in macrophage classical activation. © 2012 Elsevier B.V. All rights reserved.
DOI
10.1016/j.apsusc.2012.03.078
Appears in Collections:
조형예술대학 > 의류학전공 > Journal papers
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