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A total synthesis of aliskiren

Title
A total synthesis of aliskiren
Authors
Nam G.Ko S.Y.
Ewha Authors
고수영
SCOPUS Author ID
고수영scopus
Issue Date
2012
Journal Title
Helvetica Chimica Acta
ISSN
0018-019XJCR Link
Citation
vol. 95, no. 10, pp. 1937 - 1945
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A total synthesis of aliskiren (20) was accomplished. A key in our synthesis was to use the symmetric trans-cisoid-trans-bis-lactone 1 as a precursor. It was expediently prepared by three different routes (Scheme 2). Appending the end groups and functional group transformations completed the synthesis (Scheme 3). Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.
DOI
10.1002/hlca.201200425
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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