Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 전동원 | - |
dc.date.accessioned | 2016-08-28T10:08:56Z | - |
dc.date.available | 2016-08-28T10:08:56Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.other | OAK-9339 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223116 | - |
dc.description.abstract | Context: Chitin is the polysaccharide and is found in insects, parasites and fungi. Chitin has shown various immunological effects in in vivo and in vitro models. In this study, crystallinity controlled N-acetyl glucosamine (CCG) which has a high solubility was prepared from the low molecular weight chitosan. However, the effect of CCG in an allergic response is not clear. Objective: To investigate the effect and regulatory mechanism of CCG on allergic responses. Methods: To demonstrate the effect of CCG, we induced systemic anaphylactic shock, ear swelling response, passive cutaneous anaphylaxis (PCA), and inflammatory reaction. Results: CCG inhibited the compound 48/80-induced systemic anaphylactic shock and ear swelling responses. IgE-mediated PCA was inhibited by the oral administration or topical application of CCG. Histamine and β-hexosaminidase release from mast cells was decreased with the treatment of CCG. CCG also inhibited phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced interleukin-1β production and mRNA expression by suppressing NF-κB activation and IκBα phosphorylation. Furthermore, CCG suppressed the activation of caspase-1. Conclusion: These results suggest that CCG may have beneficial applicability as a candidate for an anti-allergic agent. © 2012 Informa Healthcare USA, Inc. | - |
dc.language | English | - |
dc.title | Anti-allergic activity of crystallinity controlled N-acetyl glucosamine | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 34 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 991 | - |
dc.relation.lastpage | 1000 | - |
dc.relation.journaltitle | Immunopharmacology and Immunotoxicology | - |
dc.identifier.doi | 10.3109/08923973.2012.684800 | - |
dc.identifier.wosid | WOS:000310314800017 | - |
dc.identifier.scopusid | 2-s2.0-84868107821 | - |
dc.author.google | Jin S.-E. | - |
dc.author.google | Jung J. | - |
dc.author.google | Jun J. | - |
dc.author.google | Jeon D.-W. | - |
dc.author.google | Kim H.-M. | - |
dc.author.google | Jeong H.-J. | - |
dc.contributor.scopusid | 전동원(9845052100) | - |
dc.date.modifydate | 20211210153349 | - |