Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정준모 | * |
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 김화정 | * |
dc.date.accessioned | 2016-08-28T10:08:54Z | - |
dc.date.available | 2016-08-28T10:08:54Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0091-3057 | * |
dc.identifier.other | OAK-9313 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223092 | - |
dc.description.abstract | In the present study, we investigated whether a novel compound, 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethylamino)-N-(3,4, 5-trimethoxybenzyl)acetamide (HYP-1), is capable of binding to voltage-gated sodium channels (VGSCs) and evaluated both its inhibitory effect on Na + currents of the rat dorsal root ganglia (DRG) sensory neuron and its in vivo analgesic activity using rat models of inflammatory and neuropathic pain. HYP-1 showed not only high affinity for rat sodium channel (site 2), but also potent inhibitory activity against the TTX-R Na+ currents of the rat DRG sensory neuron. HYP-1 co-injected with formalin (5%, 50 μl) under the plantar surface of rat hind paw dose-dependently reduced spontaneous pain behaviors during both the early and late phases. This result was confirmed by c-Fos immunofluorescence in the L4-5 spinal segments. A large number of c-Fos-positive neurons were observed in rat injected with a mixture of formalin and vehicle, but not in rat treated with a mixture of formalin and HYP-1. In addition, the effectiveness of HYP-1 (6 and 60 mg/kg, i.p.) in suppression of neuropathic pain, such as mechanical, cold and warm allodynia, induced by rat tail nerve injury was investigated. HYP-1 showed limited selectivity over hERG, N-type and T-type channels. Our present results indicate that HYP-1, as a VGSC blocker, has potential analgesic activities against nociceptive, inflammatory and neuropathic pain. © 2012 Elsevier Inc. | * |
dc.language | English | * |
dc.title | HYP-1, a novel diamide compound, relieves inflammatory and neuropathic pain in rats | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 103 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 33 | * |
dc.relation.lastpage | 42 | * |
dc.relation.journaltitle | Pharmacology Biochemistry and Behavior | * |
dc.identifier.doi | 10.1016/j.pbb.2012.07.010 | * |
dc.identifier.wosid | WOS:000309900000005 | * |
dc.identifier.scopusid | 2-s2.0-84865311962 | * |
dc.author.google | Kam Y.L. | * |
dc.author.google | Back S.K. | * |
dc.author.google | Kang B. | * |
dc.author.google | Kim Y.-Y. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Rhim H. | * |
dc.author.google | Nah S.-Y. | * |
dc.author.google | Chung J.-M. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Choi J.-S. | * |
dc.author.google | Na H.S. | * |
dc.author.google | Choo H.-Y.P. | * |
dc.contributor.scopusid | 정준모(9233608000) | * |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.date.modifydate | 20240415121825 | * |