View : 125 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author최진호-
dc.date.accessioned2016-08-28T10:08:50Z-
dc.date.available2016-08-28T10:08:50Z-
dc.date.issued2012-
dc.identifier.issn0169-1317-
dc.identifier.otherOAK-9282-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223065-
dc.description.abstractLayered double hydroxide (LDH) nanoparticles are promising candidates as delivery carriers, since they have low toxicity and can intercalate anionic drugs or genes in the interlayer spaces of two dimensional lattices. However, little information is available about their intracellular fate and trafficking pathway in human cells, which is important to improve delivery efficiency and predict toxicity potential. From the immunofluorescence and confocal microscopic studies to evaluate intracellular colocalization of fluorescein isothiocyanate-labeled nanoparticles (50 and 100. nm) with specific compartments, we found that the cellular uptake reached a maximum level at 0.5. h and gradually decreased over time. The present nanoparticles were highly colocalized with early endosomes within the first 0.5. h and largely found in an exocytic organelle, the Golgi apparatus over a period of 1-24. h. Most of 100. nm could escape a typical endo-lysosomal degradation, while 50. nm followed an endosome-lysosome pathway as well as exocytosis one with the same degree. A model for the intracellular trafficking of LDH nanoparticles depending on particle size is proposed on the basis of quantitative analysis data. © 2012 Elsevier B.V.-
dc.languageEnglish-
dc.titleIntracellular trafficking pathway of layered double hydroxide nanoparticles in human cells: Size-dependent cellular delivery-
dc.typeArticle-
dc.relation.volume65-66-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage24-
dc.relation.lastpage30-
dc.relation.journaltitleApplied Clay Science-
dc.identifier.doi10.1016/j.clay.2012.06.007-
dc.identifier.wosidWOS:000309570800005-
dc.identifier.scopusid2-s2.0-84864063366-
dc.author.googleChung H.-E.-
dc.author.googlePark D.-H.-
dc.author.googleChoy J.-H.-
dc.author.googleChoi S.-J.-
dc.contributor.scopusid최진호(8044393000)-
dc.date.modifydate20190301081000-
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE