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Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells

Title
Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells
Authors
Hong M.-N.Kim B.-C.Ko Y.-G.Lee Y.-S.Hong S.-C.Kim T.Pack J.-K.Choi H.-D.Kim N.Lee J.-S.
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2012
Journal Title
Bioelectromagnetics
ISSN
0197-8462JCR Link
Citation
vol. 33, no. 7, pp. 604 - 611
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to determine whether the exposure to either single or multiple radio-frequency (RF) radiation frequencies could induce oxidative stress in cell cultures. Exposures of human MCF10A mammary epithelial cells to either a single frequency (837MHz alone or 1950MHz alone) or multiple frequencies (837 and 1950MHz) were conducted at specific absorption rate (SAR) values of 4W/kg for 2h. During the exposure period, the temperature in the exposure chamber was maintained isothermally. Intracellular levels of reactive oxygen species (ROS), the antioxidant enzyme activity of superoxide dismutase (SOD), and the ratio of reduced/oxidized glutathione (GSH/GSSG) showed no statistically significant alterations as the result of either single or multiple RF radiation exposures. In contrast, ionizing radiation-exposed cells, used as a positive control, showed evident changes in all measured biological endpoints. These results indicate that single or multiple RF radiation exposure did not elicit oxidative stress in MCF10A cells under our exposure conditions. © 2012 Wiley Periodicals, Inc.
DOI
10.1002/bem.21731
Appears in Collections:
약학대학 > 약학과 > Journal papers
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