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Development and Validation of a Prognostic Gene-Expression Signature for Lung Adenocarcinoma

Title
Development and Validation of a Prognostic Gene-Expression Signature for Lung Adenocarcinoma
Authors
Park Y.-Y.Park E.S.Kim S.B.Kim S.C.Sohn B.H.Chu I.-S.Jeong W.Mills G.B.Byers L.A.Lee J.-S.
Ewha Authors
정우진
SCOPUS Author ID
정우진scopus
Issue Date
2012
Journal Title
PLoS ONE
ISSN
1932-6203JCR Link
Citation
vol. 7, no. 9
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Although several prognostic signatures have been developed in lung cancer, their application in clinical practice has been limited because they have not been validated in multiple independent data sets. Moreover, the lack of common genes between the signatures makes it difficult to know what biological process may be reflected or measured by the signature. By using classical data exploration approach with gene expression data from patients with lung adenocarcinoma (n = 186), we uncovered two distinct subgroups of lung adenocarcinoma and identified prognostic 193-gene gene expression signature associated with two subgroups. The signature was validated in 4 independent lung adenocarcinoma cohorts, including 556 patients. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio, 2.4; 95% confidence interval, 1.2 to 4.8; p = 0.01). An integrated analysis of the signature revealed that E2F1 plays key roles in regulating genes in the signature. Subset analysis demonstrated that the gene signature could identify high-risk patients in early stage (stage I disease), and patients who would have benefit of adjuvant chemotherapy. Thus, our study provided evidence for molecular basis of clinically relevant two distinct two subtypes of lung adenocarcinoma. © 2012 Park et al.
DOI
10.1371/journal.pone.0044225
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자연과학대학 > 생명과학전공 > Journal papers
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