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Synthesis of benzo-annulated tryptanthrins and their biological properties

Title
Synthesis of benzo-annulated tryptanthrins and their biological properties
Authors
Liang J.L.Park S.-E.Kwon Y.Jahng Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2012
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 20, no. 16, pp. 4962 - 4967
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials. © 2012 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2012.06.034
Appears in Collections:
약학대학 > 약학과 > Journal papers
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