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Syndecans play dual roles as cell adhesion receptors and docking receptors

Title
Syndecans play dual roles as cell adhesion receptors and docking receptors
Authors
Kwon M.-J.Jang B.Yi J.Y.Han I.-O.Oh E.S.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2012
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 586, no. 16, pp. 2207 - 2211
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown Copyright © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.
DOI
10.1016/j.febslet.2012.05.037
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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