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dc.contributor.author이윤실-
dc.date.accessioned2016-08-28T10:08:23Z-
dc.date.available2016-08-28T10:08:23Z-
dc.date.issued2012-
dc.identifier.issn1016-8478-
dc.identifier.otherOAK-8944-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/222784-
dc.description.abstractHyaluronic acid (HA) has been shown to promote angio-genesis. However, the mechanism behind this effect remains largely unknown. Therefore, in this study, the mechanism of HA-induced angiogenesis was examined. CD44 and PKCδ were shown to be necessary for induction of the receptor for HA-mediated cell motility (RHAMM), a HA-binding protein. RHAMM was necessary for HA-pro-moted cellular invasion and endothelial cell tube formation. Cytokine arrays showed that HA induced the expression of plasminogen activator-inhibitor-1 (PAI), a downstream target of TGFβ receptor signaling. The induction of PAI-1 was dependent on CD44 and PKCδ. HA also induced an interaction between RHAMM and TGFβ receptor I, and induction of PAI-1 was dependent on RHAMM and TGFβ receptor I. Histone deacetylase 3 (HDAC3), which is decreased by HA via rac1, reduced induction of plasminogen activator inhibitor-1 (PAI-1) by HA. ERK, which interacts with RHAMM, was necessary for induction of PAI-1 by HA. Snail, a downstream target of TGFβ signaling, was also necessary for induction of PAI-1. The down regulation of PAI-1 prevented HA from enhancing endothelial cell tube formation and from inducing expression of angiogenic factors, such as ICAM-1, VCAM-1 and MMP-2. HDAC3 also exerted reduced expression of MMP-2. In this study, we provide a novel mechanism of HA-promoted angiogenesis, which involved RHAMM-TGFβRI signaling necessary for induction of PAI-1. © 2012 KSMCB.-
dc.languageEnglish-
dc.titleHyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume33-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage563-
dc.relation.lastpage574-
dc.relation.journaltitleMolecules and Cells-
dc.identifier.doi10.1007/s10059-012-2294-1-
dc.identifier.wosidWOS:000305691100005-
dc.identifier.scopusid2-s2.0-84863466133-
dc.author.googlePark D.-
dc.author.googleKim Y.-
dc.author.googleKim H.-
dc.author.googleKim K.-
dc.author.googleLee Y.-S.-
dc.author.googleChoe J.-
dc.author.googleHahn J.-H.-
dc.author.googleLee H.-
dc.author.googleJeon J.-
dc.author.googleChoi C.-
dc.author.googleKim Y.-M.-
dc.author.googleJeoung D.-
dc.contributor.scopusid이윤실(17137192000)-
dc.date.modifydate20170601133000-
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약학대학 > 약학과 > Journal papers
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