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Beta-carboline alkaloids derived from the ascidian Synoicum sp.

Title
Beta-carboline alkaloids derived from the ascidian Synoicum sp.
Authors
Won T.H.Jeon J.-E.Lee S.-H.Rho B.J.Oh K.-B.Shin J.
Ewha Authors
노분조
SCOPUS Author ID
노분조scopusscopus
Issue Date
2012
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 20, no. 13, pp. 4082 - 4087
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y 1 (7) and six new derivatives, designated eudistomins Y 8-Y 13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na +/K +-ATPase. Structure-activity relationships were also deduced. © 2012 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2012.05.002
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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