Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:31Z | - |
dc.date.available | 2016-08-28T12:08:31Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1525-7797 | * |
dc.identifier.other | OAK-8880 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222731 | - |
dc.description.abstract | The present study reports on a thermogelling poly(ethylene glycol)-poly(l-alanine-co-l-phenyl alanine) grafted chitosan (CS-g-(PAF-PEG)) system, focusing on phase diagram, transition mechanism, and in vivo gel duration. The sol-to-gel transition temperature decreased from 27 to 11 °C as the concentration increased from 4.0 wt % to 9.0 wt %. The polymer formed micelles with 10-50 nm in diameter at 10 °C and formed large aggregates ranging from hundreds to thousands of nanometers in size as the temperature increased from 10 to 35 °C, suggesting that an extensive molecular aggregation might be involved in the sol-to-gel transition. To study the transition mechanism on a molecular level, we investigated pH, circular dichroism spectra, and 13C NMR spectra of the CS-g-(PAF-PEG) aqueous solution as a function of temperature. As the temperature increased, deprotonation of the chitosan and dehydration of the PEG were suggested, whereas the α-helical secondary structure of PAF was slightly changed in the sol-to-gel transition temperature range of 10-50 °C. A gel was formed in situ after injecting the CS-g-(PAF-PEG) aqueous solution into the subcutaneous layer of rats. About 60-70% of the gel was eliminated in 1 week, and the remaining gel was completely cleared from the implant site in 14 days. The results indicate the potential of CS-g-(PAF-PEG) as a promising short-term carrier for pharmaceutical agents. © 2012 American Chemical Society. | * |
dc.language | English | * |
dc.title | Thermogelling chitosan-g-(PAF-PEG) aqueous solution as an injectable scaffold | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1750 | * |
dc.relation.lastpage | 1757 | * |
dc.relation.journaltitle | Biomacromolecules | * |
dc.identifier.doi | 10.1021/bm300085c | * |
dc.identifier.wosid | WOS:000304978900006 | * |
dc.identifier.scopusid | 2-s2.0-84862117997 | * |
dc.author.google | Kang E.Y. | * |
dc.author.google | Moon H.J. | * |
dc.author.google | Joo M.K. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |