DSpace at EWHA: Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism

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DC Field	Value	Language
dc.contributor.author	최선	*
dc.date.accessioned	2016-08-28T12:08:23Z	-
dc.date.available	2016-08-28T12:08:23Z	-
dc.date.issued	2012	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-8778	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/222642	-
dc.description.abstract	The structure-activity relationships of N-(3-acyloxy-2-benzylpropyl)- N′-4-[(methylsulfonylamino)benzyl] thioureas, which represent simplified RTX-based vanilloids, were investigated by varying the distances between the four principal pharmacophores and assessing binding and antagonistic activity on rTRPV1. The analysis indicated that a 3-pivaloyloxy-2-benzylpropyl C-region conferred the best potency in binding affinity and antagonism. The molecular modeling of this best template with the tetrameric homology model of rTRPV1 was performed to identify its binding interactions with the receptor. © 2012 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism	*
dc.type	Article	*
dc.relation.issue	11	*
dc.relation.volume	22	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3656	*
dc.relation.lastpage	3660	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2012.04.034	*
dc.identifier.wosid	WOS:000303980600014	*
dc.identifier.scopusid	2-s2.0-84861186828	*
dc.author.google	Bhondwe R.S.	*
dc.author.google	Kang D.W.	*
dc.author.google	Kim M.S.	*
dc.author.google	Kim H.S.	*
dc.author.google	Park S.-G.	*
dc.author.google	Son K.	*
dc.author.google	Choi S.	*
dc.author.google	Lang Kuhs K.A.	*
dc.author.google	Pavlyukovets V.A.	*
dc.author.google	Pearce L.V.	*
dc.author.google	Blumberg P.M.	*
dc.author.google	Lee J.	*
dc.contributor.scopusid	최선(8659831000)	*
dc.date.modifydate	20240305081003	*