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Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation

Title
Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation
Authors
Byun M.R.Kim A.R.Hwang J.-H.Sung M.K.Lee Y.K.Hwang B.S.Rho J.-R.Hwang E.S.Hong J.-H.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2012
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 586, no. 8, pp. 1086 - 1092
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK. Structured summary of protein interactions: TAZ physically interacts with RUNX2 by pull down (View interaction). © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
DOI
10.1016/j.febslet.2012.03.008
Appears in Collections:
약학대학 > 약학과 > Journal papers
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