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Stereoselective synthesis of fluoro-homoneplanocin A as a potential antiviral agent

Title
Stereoselective synthesis of fluoro-homoneplanocin A as a potential antiviral agent
Authors
Chandra G.Majik M.S.Lee J.Y.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2012
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 14, no. 8, pp. 2134 - 2137
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Fluoro-homoneplanocin A (4) was synthesized from d-ribose, via the enyne ring-closing metathesis of 9, the stereoselective opening of epoxide 23a with fluoride, and a simultaneous oxidation-elimination reaction. The key intermediate 8 is expected to serve as a versatile intermediate for the synthesis of carbanucleosides. © 2012 American Chemical Society.
DOI
10.1021/ol300667q
Appears in Collections:
약학대학 > 약학과 > Journal papers
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