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약학대학
약학과
Journal papers
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Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma
Title
Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma
Authors
Lee Y.J.
;
Choi I.-K.
;
Sheen Y.Y.
;
Park S.N.
;
Kwon H.J.
Ewha Authors
신윤용
SCOPUS Author ID
신윤용
Issue Date
2012
Journal Title
Molecules and Cells
ISSN
1016-8478
Citation
Molecules and Cells vol. 33, no. 2, pp. 203 - 210
Indexed
SCI; SCIE; SCOPUS; KCI
Document Type
Article
Abstract
1,2-Dibromoethane and glycidol are well known genotoxic carcinogens, which have been widely used in industry. To identify a specific biomarker for these carcinogens in cells, the cellular proteome of L5178Y mouse lymphoma cells treated with these compounds was analyzed by 2-dimensional gel electrophoresis (2-DE) and MALDI-TOF mass spectrometry (MS). Of 50 protein spots showing a greater than 1.5-fold increase or decrease in intensity compared to control cells on a 2-D gel, we focused on the candidate biomarker moesin. Western analysis using monoclonal rabbit anti-moesin confirmed the identity of the protein and its increased level of expression upon exposure to the carcinogenic compounds. Moesin expression also increased in cells treated with six additional genotoxic carcinogens, verifying that moesin could serve as a biomarker to monitor phenotypic change upon exposure to genotoxic carcinogens in L5178Y mouse lymphoma cells. © 2012 KSMCB.
DOI
10.1007/s10059-012-2271-8
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