Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최원자 | - |
dc.date.accessioned | 2016-08-28T12:08:13Z | - |
dc.date.available | 2016-08-28T12:08:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | OAK-8672 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222551 | - |
dc.description.abstract | Hydrogen peroxide (H2O2) functions as a ubiquitous intracellular messenger besides as an oxidative stress molecule. This dual role is based on the distinct cellular responses against different concentrations of H2O2. Previously, we demonstrated that both low (> 1 mM) and high (4-10 mM) doses of exogenous H2O2 induce filamentous growth with distinct cell morphology and growth rate in Candida albicans, suggesting the different transcription response. In this study, we revealed that the sub-toxic and toxic levels of H2O2 indeed induced pseudohyphae, but not true hyphae. Supporting this, several hyphae-specific genes that are expressed in true hyphae induced by serum were not detected in either sub-toxic or toxic H2O2 condition. A DNA microarray analysis was conducted to reveal the transcription profiles in cells treated with sub-toxic and toxic conditions of H2O2. Under the sub-toxic condition, a small number of genes involved in cell proliferation and metabolism were up-regulated, whereas a large number of genes were up-regulated in the toxic condition where the genes required for growth and proliferation were selectively restricted. For pseudohyphal induction by sub-toxic H2O2, Cek1 MAPK activating the transcription factor Cph1 was shown to be important. The absence of expression of several hyphae-specific genes known to be downstream targets of Cph1-signaling pathway for true hyphae formation suggests that the Cek1-mediated signaling pathway is not solely responsible for pseudohyphal formation by subtoxic H 2O2 and, but instead, complex networking pathway may exists by the activation of different regulators. © 2012 KSMCB. | - |
dc.language | English | - |
dc.title | A MAP kinase pathway is implicated in the pseudohyphal induction by Hydrogen peroxide in candica albicans | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 33 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 183 | - |
dc.relation.lastpage | 193 | - |
dc.relation.journaltitle | Molecules and Cells | - |
dc.identifier.doi | 10.1007/s10059-012-2244-y | - |
dc.identifier.wosid | WOS:000302818500010 | - |
dc.identifier.scopusid | 2-s2.0-84863467035 | - |
dc.author.google | Srinivasa K. | - |
dc.author.google | Kim J. | - |
dc.author.google | Yee S. | - |
dc.author.google | Kim W. | - |
dc.author.google | Choi W. | - |
dc.contributor.scopusid | 최원자(7402515987) | - |
dc.date.modifydate | 20230210130537 | - |