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dc.contributor.author박혜영-
dc.date.accessioned2017-08-28T22:36:02Z-
dc.date.available2017-08-28T22:36:02Z-
dc.date.issued2012-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-8667-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/222547-
dc.description.abstractA series of novel N,N-dimethyl-N′-(5-(Ar-sulfonamido) benzo[d]isothiazol-3-yl)formimidamides was designed and synthesized as 5-HT 6 ligands. Here N,N-dimethyl formimidamides was used as a replacement for an aminoethyl moiety. In vitro functional assays demonstrated compounds 9b and 9i significantly inhibited the 5-HT-induced Ca 2+ increases (9b; IC 50 = 0.36 μM and 9i; IC 50 = 0.44 μM), indicating that 9b and 9i were potent 5-HT 6 receptor antagonists. Compounds 9i also showed good selectivity on the 5-HT 6 over 5-HT 4 and 5-HT 7 receptors. © 2012 Published by Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleSynthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT 6 receptor antagonists-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume20-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2707-
dc.relation.lastpage2712-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2012.02.020-
dc.identifier.wosidWOS:000302767100028-
dc.identifier.scopusid2-s2.0-84859428852-
dc.author.googleYoo E.-
dc.author.googleHayat F.-
dc.author.googleRhim H.-
dc.author.googlePark Choo H.-Y.-
dc.contributor.scopusid박혜영(34972649500)-
dc.date.modifydate20190301081000-
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약학대학 > 약학과 > Journal papers
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