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Size-dependent interactions between Au nanoparticles and DNA in electrochemical oxidation by metal complexes

Title
Size-dependent interactions between Au nanoparticles and DNA in electrochemical oxidation by metal complexes
Authors
Wu Q.Kang H.K.Oh B.N.Kim J.
Ewha Authors
김진흥
SCOPUS Author ID
김진흥scopus
Issue Date
2012
Journal Title
Journal of Physical Chemistry C
ISSN
1932-7447JCR Link
Citation
vol. 116, no. 14, pp. 8020 - 8026
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Single-stranded oligonucleotides (ssDNA) containing guanine bases in their sequences were adsorbed onto gold nanoparticles (AuNPs) by electrostatic interaction. Cyclic voltammetry of Ru(bpy) 3 2+ in the presence of the ssDNA-AuNP complex resulted in an enhanced anodic current due to the oxidation of the guanine bases of DNA. The current obtained with ssDNA-AuNP appeared much smaller than the corresponding ssDNA alone. This current reduction was due to the decrease in solvent accessibility of the guanines in ssDNA immobilized to AuNPs. A progressive decrease in the current was observed in the titration of AuNPs to ssDNA, and a minimum current was eventually obtained, indicating complete binding of ssDNA. The size dependences of AuNPs on the interaction between ssDNA and AuNP were also studied, and the ssDNA adsorbed to 5 nm AuNPs was more solvent-accessible for the Ru mediator than 13 and 30 nm AuNPs. © 2012 American Chemical Society.
DOI
10.1021/jp209470g
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자연과학대학 > 화학·나노과학전공 > Journal papers
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