Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:08Z | - |
dc.date.available | 2016-08-28T12:08:08Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-8609 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222494 | - |
dc.description.abstract | Twelve dihydroxylated 2,4,6-triphenyl pyridines were designed and synthesized which contain hydroxyl groups at ortho, meta or para position of 2- and 6-phenyl, or 2- and 4-phenyl rings attached to the central pyridine. They were evaluated for topoisomerase I and II inhibitory activity, and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Generally, dihydroxylated 2,4,6-triphenyl pyridines exhibited stronger topoisomerase II inhibitory activity, and cytotoxicity compared to those of monohydroxylated 2,4,6-triphenyl pyridines. The concrete structure-activity relationship was observed that dihydroxylated 2,4,6-triphenyl pyridines with hydroxyl group at meta or para position of 2-phenyl ring displayed significant topoisomerase II inhibitory activity as well as cytotoxicity. Positive correlation between topoisomerase II inhibitory activity and cytotoxicity was observed for compounds 10, 12, 13, 17-20 and 22. © 2012 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study | * |
dc.type | Article | * |
dc.relation.volume | 49 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 219 | * |
dc.relation.lastpage | 228 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2012.01.015 | * |
dc.identifier.wosid | WOS:000302033300022 | * |
dc.identifier.scopusid | 2-s2.0-84857239566 | * |
dc.author.google | Karki R. | * |
dc.author.google | Thapa P. | * |
dc.author.google | Yoo H.Y. | * |
dc.author.google | Kadayat T.M. | * |
dc.author.google | Park P.-H. | * |
dc.author.google | Na Y. | * |
dc.author.google | Lee E. | * |
dc.author.google | Jeon K.-H. | * |
dc.author.google | Cho W.-J. | * |
dc.author.google | Choi H. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |