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Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model

Title
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model
Authors
Hong Y.K.Lee S.Park S.H.Lee J.H.Han S.Y.Kim S.T.Kim Y.-K.Jeon S.Koo B.-S.Cho K.S.
Ewha Authors
김상태
Issue Date
2012
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 419, no. 1, pp. 49 - 53
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Amyloid-β-42 (Aβ42) has been implicated in the pathogenesis of Alzheimer's disease (AD). Neuronal Aβ42 expression induces apoptosis and decreases survival and locomotive activity in Drosophila. However, the mechanism by which Aβ42 induces these neuronal impairments is unclear. In this study, we investigated the underlying pathway in theses impairments. JNK activity was increased in Aβ42-expressing brains, and the Aβ42-induced defects were rescued by reducing JNK or caspase activity through genetic modification or pharmacological treatment. In addition, these impairments were restored by Drosophila forkhead box subgroup O (dFOXO) deficiency. These results suggest that the JNK/dFOXO pathway confers a therapeutic potential for AD. © 2012 Elsevier Inc.
DOI
10.1016/j.bbrc.2012.01.122
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자연과학대학 > 화학·나노과학전공 > Journal papers
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