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Efficient catalytic interconversion between NADH and NAD + accompanied by generation and consumption of hydrogen with a water-soluble iridium complex at ambient pressure and temperature

Title
Efficient catalytic interconversion between NADH and NAD + accompanied by generation and consumption of hydrogen with a water-soluble iridium complex at ambient pressure and temperature
Authors
Maenaka Y.Suenobu T.Fukuzumi S.
Ewha Authors
Shunichi Fukuzumi
SCOPUS Author ID
Shunichi Fukuzumiscopus
Issue Date
2012
Journal Title
Journal of the American Chemical Society
ISSN
0002-7863JCR Link
Citation
vol. 134, no. 1, pp. 367 - 374
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Regioselective hydrogenation of the oxidized form of β-nicotinamide adenine dinucleotide (NAD +) to the reduced form (NADH) with hydrogen (H 2) has successfully been achieved in the presence of a catalytic amount of a [C,N] cyclometalated organoiridium complex [Ir III(Cp)(4- (1H-pyrazol-1-yl-κN 2)benzoic acid-κC 3)(H 2O)] 2 SO 4 [1] 2·SO 4 under an atmospheric pressure of H 2 at room temperature in weakly basic water. The structure of the corresponding benzoate complex Ir III(Cp)(4-(1H-pyrazol-1-yl-κN 2)-benzoate- κC 3)(H 2O) 2 has been revealed by X-ray single-crystal structure analysis. The corresponding iridium hydride complex formed under an atmospheric pressure of H 2 undergoes the 1,4-selective hydrogenation of NAD + to form 1,4-NADH. On the other hand, in weakly acidic water the complex 1 was found to catalyze the hydrogen evolution from NADH to produce NAD + without photoirradiation at room temperature. NAD + exhibited an inhibitory behavior in both catalytic hydrogenation of NAD + with H 2 and H 2 evolution from NADH due to the binding of NAD + to the catalyst. The overall catalytic mechanism of interconversion between NADH and NAD + accompanied by generation and consumption of H 2 was revealed on the basis of the kinetic analysis and detection of the catalytic intermediates. © 2011 American Chemical Society.
DOI
10.1021/ja207785f
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자연과학대학 > 화학·나노과학전공 > Journal papers
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