Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김화정 | * |
dc.date.accessioned | 2016-08-28T12:08:02Z | - |
dc.date.available | 2016-08-28T12:08:02Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0021-924X | * |
dc.identifier.other | OAK-8535 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222427 | - |
dc.description.abstract | Screening of matrix metalloproteinase (MMP)-14 substrates in human plasma using a proteomics approach previously identified apolipoprotein A-IV (apoA-IV) as a novel substrate for MMP-14. Here, we show that among the tested MMPs, purified apoA-IV is most susceptible to cleavage by MMP-7, and that apoA-IV in plasma can be cleaved more efficiently by MMP-7 than MMP-14. Purified recombinant apoA-IV (44-kDa) was cleaved by MMP-7 into several fragments of 41, 32, 29, 27, 24, 22 and 19 kDa. N-terminal sequencing of the fragments identified two internal cleavage sites for MMP-7 in the apoA-IV sequence, between Glu 185 and Leu 186, and between Glu 262 and Leu 263. The cleavage of lipid-bound apoA-IV by MMP-7 was less efficient than that of lipid-free apoA-IV. Further, MMP-7-mediated cleavage of apoA-IV resulted in a rapid loss of its intrinsic anti-oxidant activity. Based on the fact that apoA-IV plays important roles in lipid metabolism and possesses anti-oxidant activity, we suggest that cleavage of lipid-free apoA-IV by MMP-7 has pathological implications in the development of hyperlipidemia and atherosclerosis. © 2011 The Authors. | * |
dc.language | English | * |
dc.title | Apolipoprotein A-IV is a novel substrate for matrix metalloproteinases | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 151 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 291 | * |
dc.relation.lastpage | 298 | * |
dc.relation.journaltitle | Journal of Biochemistry | * |
dc.identifier.doi | 10.1093/jb/mvr137 | * |
dc.identifier.wosid | WOS:000301066800009 | * |
dc.identifier.scopusid | 2-s2.0-84863257557 | * |
dc.author.google | Park J.Y. | * |
dc.author.google | Park J.H. | * |
dc.author.google | Jang W. | * |
dc.author.google | Hwang I.-K. | * |
dc.author.google | Kim I.J. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Cho K.-H. | * |
dc.author.google | Lee S.-T. | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.date.modifydate | 20240118124308 | * |