Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-28T12:08:55Z | - |
dc.date.available | 2016-08-28T12:08:55Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1469-221X | * |
dc.identifier.other | OAK-8466 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222361 | - |
dc.description.abstract | Sqstm1/p62 functions in the non-canonical activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). However, its physiological relevance is not certain. Here, we show that p62 -/- mice exhibited an accelerated presentation of ageing phenotypes, and tissues from these mice created a pro-oxidative environment owing to compromised mitochondrial electron transport. Accordingly, mitochondrial function rapidly declined with age in p62 -/- mice. In addition, p62 enhanced basal Nrf2 activity, conferring a higher steady-state expression of NAD(P)H dehydrogenase, quinone 1 (Nqo1) to maintain mitochondrial membrane potential and, thereby, restrict excess oxidant generation. Together, the p62-Nrf2-Nqo1 cascade functions to assure mammalian longevity by stabilizing mitochondrial integrity. © 2012 european molecular biology organization. | * |
dc.language | English | * |
dc.title | Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 150 | * |
dc.relation.lastpage | 156 | * |
dc.relation.journaltitle | EMBO Reports | * |
dc.identifier.doi | 10.1038/embor.2011.246 | * |
dc.identifier.wosid | WOS:000300407000013 | * |
dc.identifier.scopusid | 2-s2.0-84863041323 | * |
dc.author.google | Kwon J. | * |
dc.author.google | Han E. | * |
dc.author.google | Bui C.-B. | * |
dc.author.google | Shin W. | * |
dc.author.google | Lee J. | * |
dc.author.google | Lee S. | * |
dc.author.google | Choi Y.-B. | * |
dc.author.google | Lee A.-H. | * |
dc.author.google | Lee K.-H. | * |
dc.author.google | Park C. | * |
dc.author.google | Obin M.S. | * |
dc.author.google | Park S.K. | * |
dc.author.google | Seo Y.J. | * |
dc.author.google | Oh G.T. | * |
dc.author.google | Lee H.-W. | * |
dc.author.google | Shin J. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |