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Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices

Title
Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices
Authors
Hong I.Kim J.Song B.Park K.Shin K.Eom K.D.Han P.L.Lee S.Choi S.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2012
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 506, no. 1, pp. 121 - 125
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Late-phase long-term potentiation (L-LTP) of excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala (T-LA synapses) has been proposed as a cellular substrate for long-term fear memory. This notion is evidenced primarily by previous reports in which the same pharmacological treatments block both T-LA L-LTP and the consolidation of fear memory. In this study, we report that fear conditioning occludes L-LTP at T-LA synapses in brain slices prepared after fear memory consolidation. L-LTP was restored either when synaptic depotentiation was induced prior to L-LTP induction in brain slices prepared from conditioned rats or when brain slices were prepared from conditioned rats that had been exposed to subsequent fear extinction, which is a behavior paradigm known to induce in vivo synaptic depotentiation at T-LA synapses. These results suggest that fear conditioning recruits L-LTP-like mechanisms that are reversible and saturable at T-LA synapses. © 2011 Elsevier Ireland Ltd.
DOI
10.1016/j.neulet.2011.10.063
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일반대학원 > 뇌·인지과학과 > Journal papers
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