Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-08-28T12:08:54Z | - |
dc.date.available | 2016-08-28T12:08:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.other | OAK-8454 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222350 | - |
dc.description.abstract | Late-phase long-term potentiation (L-LTP) of excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala (T-LA synapses) has been proposed as a cellular substrate for long-term fear memory. This notion is evidenced primarily by previous reports in which the same pharmacological treatments block both T-LA L-LTP and the consolidation of fear memory. In this study, we report that fear conditioning occludes L-LTP at T-LA synapses in brain slices prepared after fear memory consolidation. L-LTP was restored either when synaptic depotentiation was induced prior to L-LTP induction in brain slices prepared from conditioned rats or when brain slices were prepared from conditioned rats that had been exposed to subsequent fear extinction, which is a behavior paradigm known to induce in vivo synaptic depotentiation at T-LA synapses. These results suggest that fear conditioning recruits L-LTP-like mechanisms that are reversible and saturable at T-LA synapses. © 2011 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 506 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 121 | - |
dc.relation.lastpage | 125 | - |
dc.relation.journaltitle | Neuroscience Letters | - |
dc.identifier.doi | 10.1016/j.neulet.2011.10.063 | - |
dc.identifier.wosid | WOS:000300205000025 | - |
dc.identifier.scopusid | 2-s2.0-84855195444 | - |
dc.author.google | Hong I. | - |
dc.author.google | Kim J. | - |
dc.author.google | Song B. | - |
dc.author.google | Park K. | - |
dc.author.google | Shin K. | - |
dc.author.google | Eom K.D. | - |
dc.author.google | Han P.L. | - |
dc.author.google | Lee S. | - |
dc.author.google | Choi S. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |