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Extremely low frequency magnetic fields do not elicit oxidativestress in MCF10A cells

Title
Extremely low frequency magnetic fields do not elicit oxidativestress in MCF10A cells
Authors
Hong M-N.Han N.-K.Lee H.-C.Ko Y.-K.Chi S.-G.Lee Y.-S.Gimm Y.-M.Myung S.-H.Lee J.-S.
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2012
Journal Title
Journal of Radiation Research
ISSN
0449-3060JCR Link
Citation
vol. 53, no. 1, pp. 79 - 86
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to determine whether extremely low frequency magnetic fields (ELF-MF) could affect intracellular reactive oxygen species (ROS) levels and antioxidant enzyme activity. After MCF10A human breast epithelial cells were exposed to 1 mT of 60 Hz ELF-MF for 4 hours, intracellular ROS level, superoxide dismutase (SOD) activity, and reduced to oxidized glutathione (GSH/GSSG) ratio were measured. The cells exposed to ELF-MF did not evidence statistically significant changes in the above-mentioned biological parameters as compared to either the incubator controls or sham-exposed cells. By way of contrast, the IR-exposed cells exhibited marked changes in ROS level, SOD activity, and GSH/GSSG ratio. When we assessed morphological changes and senescence-associated beta-galactosidase (SA-β-Gal) activity, only the IR-exposed cells were positive. According to our results, it could be concluded that ELF-MF has no effect on intracellular ROS level, SOD activity, and GSH/GSSG ratio under our exposure condition.
DOI
10.1269/jrr.11049
Appears in Collections:
약학대학 > 약학과 > Journal papers
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