Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:53Z | - |
dc.date.available | 2016-08-28T12:08:53Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.other | OAK-8439 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222336 | - |
dc.description.abstract | Conformationally restricted 2′-C-azido-, hydroxy- and fluoromethyl-carbanucleosides 4b-f were efficiently synthesized via the stereoselective conversion of ketone 7 to epoxide 14, followed by the stereoselective opening of the epoxide with nucleophiles (OAc, N 3, and F), while the corresponding 2′-C-methyl-carbanucleoside 4a was synthesized via the stereoselective Grignard reaction of ketone 7 with methylmagnesium iodide as a key step. All the final nucleosides 4a-f were assayed for anti-HCV activity, but showed neither significant anti-HCV activity nor cytotoxicity in a cell-based replicon assay. © 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Stereoselective synthesis and anti-HCV activity of conformationally restricted 2′-C-substituted carbanucleosides | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 68 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1253 | - |
dc.relation.lastpage | 1261 | - |
dc.relation.journaltitle | Tetrahedron | - |
dc.identifier.doi | 10.1016/j.tet.2011.11.052 | - |
dc.identifier.wosid | WOS:000300028800038 | - |
dc.identifier.scopusid | 2-s2.0-84855434348 | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Ko Y.J. | - |
dc.author.google | Chandra G. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Koh H.J. | - |
dc.author.google | Moon H.R. | - |
dc.author.google | Jung Y.H. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |